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Converging relationships of obesity and hyperuricemia with special reference to metabolic disorders and plausible therapeutic implications [J]

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Compared to fish fed HFD, the expression levels of sirt1 and ppar genes in liver were significantly up-regulated in fish fed the diets with betaine supplementation, whereas hepatic expression of the srebp-1 gene was lower, albeit not significantly, in fish fed the HFD+B2 diet ( Figure 6A )