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Science 374 , eabh2444 (2021)

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These findings suggest that manoeuvres designed to increase mucosal GSH content may be useful to withstand the lethal consequences of oxidative stress that may contribute to attenuate the activation and recruitment of related factors that participate in the development of IBD, including VCAM-1 and ICAM-1 (Sans et al, 1999)

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Although Breslow thickness and lymph node metastasis are still regarded as poor prognostic indicators, melanoma cells' tendency to infiltrate distant organs likewise relies on how they interact with other cells in the tumor microenvironment (TME) and the manner in which the immune system responds