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Inflammation of the brain in Alzheimer's disease: implications for therapy

Genetic or pharmacological blockade of Parkin abolishes its benefit, underscoring mitophagy as the critical driver ( Urolithin A, a gut-derived ellagitannin metabolite, similarly boosts PINK1-Parkin-dependent mitophagy, thereby dampening ROS-mediated NLRP3 priming, Caspase-1 cleavage and GSDMD-driven pyroptosis

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In this case also the increase in TSH level was not statistically significant between the groups