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For instance, astrocytes can significantly inhibit glutamate release by interacting with A1 receptors (A1R) and facilitating the breakdown of ATP into adenosine in the synaptic space

Silent ischaemia, which is common among patients with diabetes or autonomic neuropathy, presents distinctive diagnostic challenges due to the presence of atypical symptoms, further complicating early detection and resulting in profound complications [1]

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Hcy is produced in the methionine cycle, where it can be remethylated to methionine, converted to thiolactone, or sent down the transsulfuration pathway toward glutathione by the enzyme cystathionine beta-synthase (CBS)

In addition, we also found that the increase of mitochondrial membrane potential (Fig