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In the case of iron metabolic disorder, the low expression of FTH1 and the overexpression of TFR1 often lead to the excessive accumulation of Fe 2+ ions, which induce the production and accumulation of a large amount of ROS through Fenton reaction and eventually promote cell ferroptosis ( Lipid Peroxidation Lipid peroxidation plays a driving role in the occurrence of ferroptosis, which can be completed by non-enzymatic or enzymatic reaction

Transport mechanism of NPTAs The translocation of drugs across the BBB to the brain mainly depends on passive diffusion and active transport mechanisms

These studies support the concept of chrononutrition dietary choices (both content and timing) can serve as adjunct therapies to strengthen circadian rhythms and ameliorate age-related sleep/circadian disturbances ( It is evident from the above that diet and nutrients offer promising tools to combat circadian and sleep disturbances in aging

When NGF levels drop due to aging or chronic stress, we experience slower learning, poor memory recall, and a general sense of mental rigidity

What is truly promising is that there appears to be little to no toxicity in non-neoplastic cells

& Rathbone, J