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Significant in the maintenance of our metabolism, blood cells, and nerve function

The EEG findings in individuals with biotinase deficiency commonly reveal burst suppression and multifocal spikes [72]

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Concurrent administration of pyridoxine with these medications has been reported to lower their therapeutic levels, so monitoring and dosage adjustments of the anticonvulsant might be required if high-dose vitamin B is given

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The trial is also designed to provide information on the effect of the normalisation of serum vitamin B12 concentrations by both treatments on patient-perceived quality of life