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1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase

Wacker M, Holick MF (2013) Sunlight and Vitamin D: a global perspective for health

Yet our bodies need for energy is constant (though variable) in particular, we need a constant supply of glucose, as this is the only nutrient that certain parts of the brain can utilise

Niwa, and L

The disease shows the highest prevalence in Latin America, Eastern/Central Europe, as well as the Middle East and the southern part of Africa (203)

Yagishita, Y., Uruno, A., Chartoumpekis, D