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In recreational athletes, supraphysiological GH doses are often used either alone or in combination with other doping substances (140), and studies have shown that GH improves anaerobic sprint capacity, but not strength and endurance (141), and increases GH, IGF-I and fasting insulin levels (142, 143) mimicking those seen in acromegaly patients ( Table 1 )

Indeed, contradictory findings suggest that excess Cu 2+ may induce cell death via apoptosis, 249 caspase-independent cell death, or an accumulation of ROS

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Comparative analysis showed that D-CuP exhibited higher binding affinities than its monomeric counterpart M-CuP, with Vina scores of -5.7 kcal/mol for p53 and -6.4 kcal/mol for HDAC7, compared to -4.2 kcal/mol and -4.8 kcal/mol for M-CuP, respectively (Fig