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Interestingly, clinical studies have demonstrated that the combined application of dehydroepiandrosterone (DHEA) and CoQ10 in patients with diminished ovarian reserve can significantly enhance the number of antral follicles and improve ovarian responsiveness during intrauterine insemination and IVF cycles

In POF, the ovaries lose their germinative and hormonal functions because of the exhaustion of the number of ovarian follicles before the typical age for physiological menopause which is around 50 years of age

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This damage comes from both internal and external factors

Notably, zearalenone (ZEN) disrupts oocyte-cumulus cell interactions, delays cell cycle progression, and induces cytoskeletal abnormalities