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Peroxynitrite has a direct effect on mitochondria leading to lipid peroxidation of membrane lipids and thus damaging the complexes of the respiratory chain and mitochondrial DNA

Cell scattering which is the hallmark of an HGF/c-Met interaction, leads to a loss of cell adhesion properties that allow cells to migrate

There are 3 distinct variants of the superoxide dismutase enzyme: copper-zinccontaining enzymes in the cytoplasm, manganese SOD in the mitochondria, and nickel SOD in the extracellular environment

This indicates that erastin-induced ferroptosis is associated with upregulation of CHAC1

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Khanna, P