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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr

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Fatty acid transport protein 4 (FATP4) further promotes intracellular retention of ALA through acyl-CoA formation, while members of the fatty acid-binding protein (FABP) family (I-FABP, L-FABP, FABPpm) chaperone -3 PUFAs toward the endoplasmic reticulum for re-esterification (5860)

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In addition, ATOX1 can bind Cu and act as a transcription factor by associating with the promoters of specific genes (e.g., cyclin D1), thereby driving their expression and promoting cell proliferation (Itoh et al., 2008) (Figure 1