Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus
45 In fact, the preexisting P-selectin in Weibel-Palade bodies is the fastest expressed selectin
Oral supplements are taken daily, while injection schedules depend on the individuals goals and the healthcare providers recommendations
Cell viability assay of MIA PaCa-2 and PANC-1 cells after knockdown of TXNDC12, (B)
Surez M, Boqu N, del Bas JM, Mayneris-Perxachs J, Arola L, Caimari A
Abbreviations I/R: Ischemiareperfusion IRI: Ischemiareperfusion injury OIRIs: Organ ischemiareperfusion injuries RCD: Regulated cell death ROS: Reactive oxygen species PUFA: Polyunsaturated fatty acid LOX: Lipoxygenase Lipid-OOH: Lipid peroxides TF: Transferrin TfR1: Transferrin receptor protein-1 STEAP3: Prostate six-transmembrane epithelial antigen 3 DMT1: Divalent metal transporter 1 LIP: Labile iron pool PCBP1: Poly-(rC)-binding protein 1 PCBP2: Poly-(rC)-binding protein 2 FPN1: Ferroportin SLC7A11: Solute carrier family 7 member 11 xCT: Cysteine/glutamate transporter SLC3A2: Solute carrier family 3 member 2 4F2hc: 4F2 heavy chain GSH: Glutathione OH: Hydroxyl radicals O2 : Superoxide anions H2O2: Hydrogen peroxide GPX: Glutathione peroxidases Lipid-OH: Lipid alcohol GSSG: Glutathione disulfide GR: Glutathione reductase NADPH: Nicotinamide-adenine dinucleotide phosphate FA: Fatty acid PL: Phospholipid SFA: Saturated fatty acid MUFA: Monounsaturated fatty acid PUFA: Polyunsaturated fatty acid ACSL4: Acyl-CoA synthetase long-chain family member-4 LPCAT3: Lysophosphatidylcholine acyltransferase-3 PE: Phosphatidylethanolamine AA: Arachidonic acid AdA: Adrenic acid MDA: Malondialdehyde 4-HNE: 4-Hydroxy-2-nonenal IIRI: Intestinal ischemiareperfusion injury CAT: Capsiate TRPV1: Transient receptor potential cation channel subfamily V member 1 H/R: Hypoxia-reoxygenation Sp1: Special protein 1 APG: Apigenin-7-O--D-(-6-p-coumaroyl)-glucopyranoside HO-1: Heme oxygenase 1 MAO-B: Monoamine oxidase b ALI: Acute lung injury Nrf2: Nuclear factor erythroid 2-related factor 2 ARE: Antioxidant reaction element Nrf2 / : Nuclear factor erythroid 2-related factor 2 gene knockout TERT: Telomerase reverse transcriptase STAT3: Signal transducer and activator of transcription 3 BCAA: Branched-chain amino acids L-BAIBA: L--aminoisobutyric acid LIRI: Lung ischemiareperfusion injury MIRI: Myocardial ischemiareperfusion injury USP7: Ubiquitin-specific protease 7 FTH1: Ferritin heavy chain 1 ALOX15: Arachidonate 15-lipoxygenase 15-HpETE: 15-Hydroperoxyeicosatetraenoic acid Pgc1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha RNF34: Ubiquitin ligase ring finger protein 34 KMT2B: Lysine-specific methyltransferase 2B RFK: Riboflavin kinase TNF: Tumor necrosis factor NOX2: Nicotinamide-adenine dinucleotide phosphate oxidase 2 ATF3: Activating transcription factor 3 FANCD2: Fanconi anemia complementation group D2 RIRI: Renal ischemiareperfusion injury AKI: Acute kidney injury Dex: Dexmedetomidine 2-AR: 2-Adrenergic receptor OGD/R: Oxygenglucose deprivation and reoxygenation USC: Urine-derived stem cell USC-Exo: Urine-derived stem cell-derived exosome TUG1: Taurine-upregulated gene 1 SRSF1: Serine/arginine splicing factor 1 IRE1: Inositol requiring enzyme 1 JNK: C-Jun NH2-terminal kinases CCL2: Chemokine (CC motif) ligand 2 CCL7: Chemokine (CC motif) ligand 7 HIRI: Hepatic ischemiareperfusion injury LT: Liver transplantation Ptgs2: Prostaglandin-endoperoxide synthase 2 TMEM16A: Transmembrane member 16A MSC-Exo: Mesenchymal stem cell-derived exosome miR: MicroRNA BMMSC: Bone marrow mesenchymal stem cell IREB2: Iron response element-binding protein 2 MCTR1: Maresin conjugate 1 in tissue regeneration DMF: Dimethyl fumarate ME1: Malic enzyme 1 PTEN: Phosphatase and tensin homolog mTOR: Mechanistic target of rapamycin SREBP1: Sterol regulatory element-binding protein 1 IS: Ischemic stroke CIRI: Cerebral ischemiareperfusion injury NQO1: Quinone oxidoreductase 1 MCAO/R: Middle cerebral artery occlusion and reperfusion ELA: Elabela APJ: Apelin receptor NLRP3: Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 FACL4: Fatty acid-CoA ligase 4 PGE2: Prostaglandin E2 COX: Cyclooxygenase NCOA4: Nuclear receptor coactivator 4 SOD: Superoxide dismutase LDH: Lactate dehydrogenase LPO: Lipid peroxidase HETE: Hydroxyeicosatetraenoic acid ALT: Alanine aminotransferase AST: Aspartate aminotransferase HNF4: Hepatocyte nuclear factor-4 References Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death
