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(2002) Nonobese diabetic (NOD) mouse dendritic cells stimulate insulin secretion by prediabetic islets Autoimmunity, 35, 449-4551059 4

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Clinician insight: Improvements paralleled reductions in toxin load and oxidative stress, better sleep/circadian alignment, microbiome balance, and mitochondrial support addressing drivers , not just numbers

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Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O, Tabas I

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showed that mitochondrial biogenesis could also be regulated by circadian clock genes REV-ERBs [50, 51]

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