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Similarly, infection of alveolar pneumocytes cells by SARS-CoV-2 virus triggers the initiation of systemic inflammation and elevated immunoreactivity that potentiate T-cell and macrophage activation infiltrating infected myocardial tissues, leading to cardiovascular damage and myocarditis

Furthermore, descending inhibitory pathways, which modulate the visceral pain signal by releasing neurotransmitters such as opioids, noradrenaline, dopamine and 5-HT [94], are down-regulated in IBS patients as indicated by an increased somatic sensitivity [95]

Neurochem Res 21:122 Al-Kuraishy HM, Al-Gareeb AI, Saad HM, Batiha GE (2022) Benzodiazepines in Alzheimers disease: beneficial or detrimental effects

Benevenuto D, Saxena K, Fries GR, Valvassori SS, Kahlon R, Saxena J, et al

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Additionally, the issue is exacerbated by traditional laboratories setting the 'normal' range too low, which may result in undiagnosed B12 deficiencies