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Hi Dr Doni, Great article

Prokaryotic evolution in light of gene transfer

It remains however important to note that since this uPAR15 sdAb only recognizes the human homolog of uPAR, the murine uPAR expression on tumor-associated stromal cells in the tumor microenvironment does not contribute to the tracers uptake, hereby underestimating the total tumor accumulation potential in a human situation (56)

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(2) Cellular metabolites Cellular metabolites encompass various components, including extracellular polysaccharides (EPSs), short-chain fatty acids (SCFAs), organic acids, enzymes, vitamins, and bacteriocins