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Two key regulatory pathways (p16-CDK4-RB and ARF-MDM2-p53 pathway) are involved in controlling cells duplication activities from unrestrained progression of cell cycles, whereby the principal proteins involved in these distinct pathways are retinoblastoma tumor suppressor protein (RB) and p53 tumor suppressor protein (Fig

Although correlations between systemic inflammatory markers and gut dysbiosis are observed in clinical patients, direct histological evidence of bacterial translocation is difficult to obtain in humans