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S-adenosylmethionine (SAMe), which serves as a direct precursor to glutathione, is currently being evaluated for its safety, efficacy, and effectiveness in an ongoing phase 4 randomized clinical trial (NCT02024295) for patients with AH and patients with alcohol-associated cirrhosis (NCT04250259)

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Targeting this increase in GCL activity using BSO (the irreversible GCL inhibitor) is now often used as an adjuvant chemotherapeutic agent in cancer treatment [13]