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During IDD, the increased catabolic activity along with the gradual reduction of functional cells (due to both cell apoptosis and the acquisition of a defective senescent phenotype) of the intervertebral disc (IVD) dramatically reduces its capacity to produce an adequate amount of extracellular matrix (ECM) and preserve its structural integrity

What makes GI research particularly compelling is that it resists simple answers

Friden PM, Walus LR, Musso GF, Taylor MA, Malfroy B, Starzyk RM

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