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This difference can be explained by the fact that GBM has a stiff mechanical environment in the brain, which upregulates the expression of Piezo1 ( Figure 2 The expression of Piezo1 can result in mechanical stimulation between glioma cells and promote the occurrence and development of tumors (Hong et al., 2023)

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A pre-ranked gene list of the Bru-Seq data set was submitted to GSEA, and enrichment analysis was done based on the KolmogorovSmirnov statistic 59,60

At the molecular level, semaglutide's mechanism of action involves the GLP-1 receptor (GLP-1R), a G-protein coupled receptor [8]

Epilepsia 52 , 16351644 (2011)

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