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J Cell Mol Med 8:201212 Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis

This oxidative burst serves dual roles: while moderate ROS levels activate antiviral signaling, excessive ROS production triggers mitochondrial permeability transition, mtDNA release, and cell death ( HCV infection is strongly associated with mitochondrial ROS overproduction, driven by impaired electron flow in ETC complexes I and III and augmented calcium influx into mitochondria (Uchida et al., 2020)