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Studies have shown that caffeic acid can inhibit the expression of Keap1, reduce the stabilization of the Keap1 and Nrf2 complex, thereby activate Nrf2 and upregulate the expression of downstream antioxidant enzymes NQO1 and HO-1 (Pang et al., 2016)

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6b, Nrf2 enters the nucleus and stimulates the synthesis of these defensive enzymes (Pereira And Oakley 2008)

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Found in every cell, glutathione is most abundant in the liver, where it plays a crucial role in the formation of the enzyme glutathione peroxidase one of the most potent antioxidants in the body

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