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EPA generated a guideline to report the release of MC exceeding 1000 ppm

In addition to the Leu198Leu genotype in the GPx1 gene, the Ala16Ala genotype in the manganese superoxide dismutase ( MnSOD ) gene, the most significant enzyme that protects against ROS in the human body [90], was also associated with an increased risk of breast cancer [91]

Moreover, the serum level of IL-6 in lipopolysaccharide(LPS)-stimulated mice was significantly elevated compared to normal controls, further supporting the accuracy and effectiveness of this delivery strategy