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BDNF is crucial for neuronal survival, growth, and synaptic plasticity (Baghcheghi et al

This adverse effect can be prevented by prior treatment with mesna (mercaptoethane sulphonic acid), which possesses both a thiol group for cytoprotection and a highly polar sulphonic acid group, and results in high renal excretion and delivery of this cytoprotective molecule to the bladder epithelium

First-pass metabolism: Anything that survives the gut must pass through the liver, where it may be further processed before reaching the rest of the body

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Ferroptosis, characterized by GPX4 inhibition and iron-dependent lipid peroxidation, occurs in iron-rich cells such as glioblastomas and neurons, and is often triggered by decreased SLC7A11 expression or cystine depletion