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Carbon monoxide Carbon monoxide is a potent vasodilator and promotes NO release.59 Endogenously, the production of CO results from the breakdown of senescent erythrocytes through the heme oxidase pathway (a process known as iron scavenging).60 In vitro, not only does V-B12 bind CO, but reduced V-B12 also catalyzes an oxidation of CO to carbon dioxide using ascorbate as a cofactor.7,8 Ascorbic acid can rapidly reduce/supply electrons to V-B12 to generate the reduced or Co 2+ state and super-reduced or Co 1+ forms

Consequently, a highly significant reduction in systemic gut inflammation is achieved through this multi-targeted healing cascade

Tendon healing In a rat model in the Journal of Applied Physiology , BPC-157 accelerated tendon healing by promoting tendon-cell outgrowth, cell survival and cell migration, which the authors linked to the VEGF and nitric-oxide pathways [2]

Why is B12 added to semaglutide

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It is particularly useful when combined with Vitamin B12 for those following keto or weight-loss regimens