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The mechanisms of cellular uptake were explored by addition of free targeting ligands, endocytic and metabolic inhibitors, co-localization of nanocarriers with intracellular organs, and surface charge modification of cells

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Introduction Non-alcoholic fatty liver disease (NAFLD) is currently the most predominant chronic liver disease worldwide and is a clinicopathological syndrome ( Gentiopicroside (GPS), a type of iridoid glycosides component extracted from the Chinese herbal medicine Gentiana manshurica Kitag., Gentiana scabra Bunge., Gentiana triflora pall or Gentiana rigescens Franch., is also the main active ingredient of this herbal medicine and has anti-inflammatory, hypolipidemic, and antioxidant effects ( Recent studies have found a close association between metabolites and intestinal flora and NAFLD pathogenesis ( Therefore, in this study, we performed untargeted metabolomics and 16S gut microbiome sequencing studies on high-fat diet (HFD) -induced mice sera

Aroma contributing volatiles In various fruits, flowers and spices monoterpens and norisoprenoids (apocarotenals) are the key compounds producing characteristic scent