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Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136

Li HN, Zimmerman M, Milledge GZ, Hou XL, Cheng J, Wang ZH, Li PA (2017a) Water-soluble coenzyme Q10 reduces rotenone-induced mitochondrial fission

B cells, dendritic cells, and activated T cells all express HLA class II molecules (Nepovimova et al., 2019)

In the cytosol, glutamine can also be converted to glutamate by donation of its -nitrogen for nucleotide synthesis (pyrimidine metabolism)

BENEFITS: Antioxidant

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