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Clinical Toxicology

AOD-9604 vs Tesamorelin Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates natural growth hormone production with particular effectiveness for reducing visceral adipose tissue

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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis