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GHK-Cus mechanism depends on gradual tissue accumulation over the cycle, not on high single-day concentrations

The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences

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Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

242,244 A large population study of more than 20,000 adults ranging from 4079 years of age followed the individuals for an average of 9.5 years and found that those in the top quartile of baseline plasma vitamin C concentration had a 42% lower risk of stroke than those in the bottom quartile

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