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Accordingly, several gut metabolic dysfunctions could contribute to long-term neuro-cognitive impairments in PASC, including: (i) perturbed gut-brain axis due to loss of SCFA producing intestinal flora, which may cause neuropsychiatric disorders 728

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FIGURE 2 Caloric Sugars and Non-Caloric Sweeteners May Utilize Distinct Pathways Before the discovery of the sweet taste receptor, taste bud cells responses to caloric and non-caloric sweeteners were proposed to be mediated by two different pathways

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Maximum ion injection time was set to 50 ms (MS1) and 35 ms (MS2) with an AGC target set to 1 10 6 and 1 10 4 , respectively