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Serious but rare adverse effects require immediate medical attention and include: Pancreatitis severe, persistent abdominal pain radiating to the back, often with nausea and vomiting

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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells

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[24] Acute promyelocytic leukemia (APL) has been shown to respond well to RA, but not to cRA