glutathione high or low in acetaminopen overdose usmle What substance depletion causes hepatic necrosis from acetaminophen ? Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Overdose of acetaminophen most likely results in hepatic necrosis due to depletion of glutathione Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect A Possible Antidote for Tylenol (Paracetamol) Overdose ACSH

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