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J Biol Chem 280:3742337429 Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM et al (2017) Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

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Nevertheless, it is possible that positive feedback between the two systems is required for ample Ca 2+ accumulation to occur to induce increases in AMPK and affect feeding