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10.1016/s0166-2236(03)00162-0 60 KatoT.FunakoshiH.KadoyamaK.NomaS.KanaiM.Ohya-ShimadaW.et al (2012)

A typical loading approach might use 0.75mg to 1mg daily for the first 3 to 5 days, then reduce to 0.5mg for the remainder of the protocol

Case Description A seven-year-old Hispanic female, with no past medical history, presented to our clinic with left knee pain and progressive limp which developed over the previous two months

This is considered a favorable alternative to orally bioavailable PDE5 inhibitors that show poor results in subjects with acute metabolic disease [10, 15, 16]