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TQ interfered with TNF- signaling to modulate IL-6 and IL-8 expression and downregulated IL-8 and ICAM-1/VCAM-1 expression in rheumatoid arthritis (337)

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

Understand the evolving FDA regulatory landscape for therapeutic peptides

The beneficial effects of flavonoid CD38 inhibitors were reported in animal models of obesity, heart ischemia, kidney injury, viral infection, and cancer [71-77]

The drug is registered by the Ministry of Health, Labour and Social Welfare of Georgia (registration certificate No.003658) and approved for use in T2DM either independently or in combination with other hypoglycemic agents (Kemertelidze et al., 2012)