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Description

Biomaterials 35 , 54625471 (2014)

Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase

10.1111/j.1365-313X.2006.03015.x 74 PerteaM.PerteaG

This reduction leads to an increase in reactive oxygen species (ROS) like hydroxyl radicals, hydrogen peroxide, and superoxide ions

Additionally, funding agencies can also consider funding for degradation and toxicity studies that use high dimensional techniques such as siRNA seq, mass cytometry, and special transcriptomics to demonstrate single cell and tissue level toxicity of degradation products