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Antioxidants 11:606

Conversely, in liver cancer cell lines Huh7 and Hep3B, as well as in mice with subcutaneous tumor grafts, metformin increases ROS and lipid peroxidation levels, induces ferroptosis in liver cancer cells, and enhances their sensitivity to sorafenib [223, 277]

Phylogenetical analysis of multi-regional WGS on HCCs demonstrated that the trunk mutations rarely harbored Sig dMMR , while branch or progressor mutations had higher rate of Sig dMMR