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Most considerations of non-animal alternatives for skin irritation/sensitization testing tend to examine a single aspect of the process (e.g., chemical reactivity, epidermal bioavailability, dendritic cell responses)

Unlike most other B vitamins, B12 requires a complex process involving the stomach and intestines to be properly absorbed

It's made by stomach cells

I suppose a better question is whether that prior determination should have happened at all

Amber vials or secondary containers provide additional protection

For weight management purposes specifically , B12 injections are not recommended unless an underlying deficiency is confirmed