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Group 3, labeled the hydroxide-ROSup group, involved ROS-associated jaw defect mice treated with 100 g/mL hydroxide dissolved in saline ( n = 3)

Based on these findings, GPX protein content significantly elevated after treatment

Initially, in response to radiation injury, macrophages adopt a pro-inflammatory M1 phenotype

Noble-Haeusslein LJ

The metabolic reprogramming is executed by activation of several transcription factors, such as HIF, HK2, lactate dehydrogenase 5 (LDH5), lactate dehydrogenase A (LDHA), PDK1, PI3K, Akt, mTOR, EGFR, etc., which induce the Warburg effect, suppress oxidative metabolism in mitochondria, limit pyruvate entry into the tricarboxylic acid (TCA) cycle, trigger anabolism, and endorse lactate formation

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