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3 days) causes nuclear exclusion of active p53 and induces apoptosis in senescent TM3 Leydig cells [1]

Melatonin is a hormone directly involved in regulating sleep-wake cycles

Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells: modulation of EGF-induced trafficking and signaling

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Therefore, successful therapies must selectively interfere with the myofibroblast-specific functional traits rather than broadly inhibiting all fibroblast activities