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For instance, on average, it can take more than 15 years and over 800 million USD to bring a single novel drug to market [47]

The use of locally sourced medicinal plants could reduce reliance on expensive imported medications, making treatment more sustainable and economically feasible

Concurrently, the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome acts as a key mediator of innate immune responses and has been increasingly implicated in neuroinflammatory cascades leading to neuronal loss in PD

J Pineal Res 59(4):403419 Lissoni P, Pittalis S, Rovelli F, Zecchini S, Casati M, Tremolada M et al (1996) Immunomodulatory properties of a pineal indole hormone other than melatonin, the 5-methoxytryptophol

Patient subgroups, characterized by distinct symptom profiles and comorbidities, exhibited increased responses to specific treatments, e.g., a POTS-dominant cluster benefiting from autonomic modulators and a cognitive-dysfunction cluster from CNS stimulants

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