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Hypoxia has been posited as a possible link between vascular dysfunction and calciphylaxis in MS (179), where vascular dysfunction with defective angiogenesis leads to recurrent episodes of ischemia-reperfusion injury, increasing the products of oxidative stress, which results in tissue hypoxia (180)

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doi: 10.1152/ajpcell.00205.2022

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Byrne JA, Grieve DJ, Cave AC, Shah AM: Oxidative stress and heart failure