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Previous studies have demonstrated that fluoromethylcholine (FMC), a non-lethal, microbe-friendly inhibitor of CutC lyase, significantly reduces plasma TMAO levels by irreversibly modifying the enzymatic pair CutC/D within gut microbiota harboring the corresponding gene cluster (Benson et al., 2023)

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Literature data supported the potential role of mitochondrial dysfunctions (i.e., altered ATP production) in the onset of CFS symptoms such as fatigue and post exertional malaise (Morris and Maes 2014)