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Establishing international, standardized perioperative databases for ESCC, with uniform standards for data collection, marker measurement, and complication definitions [e.g., using the Esophagectomy Complications Consensus Group (ECCG) criteria], is crucial for developing and validating universally applicable prediction models and intervention strategies ( 6.4 Challenges and opportunities for clinical translation Translating these research findings into daily clinical practice still faces challenges, including how to standardize testing and reporting, how to determine universally applicable cut-off values, how to integrate complex models into busy clinical workflows, and the cost-effectiveness of novel markers and technologies

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