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Social Life of senescent cells: what Is SASP and why study it

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Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S (2022) Pathological structural conversion of alpha-synuclein at the mitochondria induces neuronal toxicity

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After expansion (days 8-12), they will regain their usual morphology of round and clearly defined cells

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Like erastin, a compound termed RSL3 can also induce nonapoptotic cell death [18, 19]

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