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HoloTC concentrations followed a similar trend, with the loading dose regimen reaching a median of 300 pmol/L initially, then decreasing to 184 pmol/L at 90 days

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No proven upside to offset even mild risk: When benefit is uncertain, small and infrequent risks matter more Lipo-C should not displace interventions with strong outcome data (diet, activity, and, where indicated, approved pharmacotherapy)