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33,34,35,36 Adiponectin signaling pathway As a risk factor of asthma, obesity has been associated with increased airway inflammation, AHR, oxidative stress, inducible nitric oxide synthase (iNOS) expression, and elevated nitric oxide (NO) levels

aeruginosa in the gut [80]

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When activated, Nrf2 upregulates protective antioxidant enzymes, including superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPX1) (Qian et al, 2026)4