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Furthermore, the ablation of GPX4 in neutrophils exacerbates the development of autoimmune diseases, such as systemic lupus erythematosus, by inducing ferroptosis [39]

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As a result, the antioxidant hypothesis ASD remains supported largely by preclinical evidence and by indirect clinical observations rather than by robust biochemical validation in patients

Raza H, John A, Brown EM, Benedict S, Kambal A (2008) Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells

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Regular daily or scheduled dosing keeps receptors engaged evenly