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Future investigations based on the MAD theory should take care when taking approaches to target only single microbes such as HSV-1 or else using a broad-spectrum antibiotic without an anti-biofilm measure, as such strategies would likely be only partially productive

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[61,] [62 ]These results were criticized on a number of grounds, including the noticeable difference between the vitamin C and placebo, lack of intravenous administration, and termination of treatment with tumor progression

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D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 exhibited no detectable metabolism over 90 min in an in-vitro metabolism assay using rat liver microsomes (data not shown)