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GHK peptides are potent anti-inflammatory agents

doi: 10.1007/s11064-018-2651-3 174

INTRODUCTION Cancer is characterized as a complex disease that includes the change of gene expression, sustains cell survival and proliferation, and can be modified by genomic and epigenomic factors.[] Cancer disease is a major health problem and considered one of the main causes of mortality around the world.[] After lung cancer, colon cancer is the second most prevalent cause of cancer death in men and women.[] Further, among cancers, breast cancer is known as the most common cancer and the second leading cause of death from cancer in women worldwide.[] A high level of oxidative stress is very suitable conditions for cancer cell operation due to oncogenic transformation, high baseline levels of reactive oxygen species (ROS), and metabolic reprogramming.[] In 2012, according to the Brazilian National Cancer Institute (INCA, in the Portuguese acronym), there were 14.1 million women and men suffering from cancer disease in the world, with a total of 8.2 million deaths from the disease.[] Selenium (Se) as a trace element is essential and unique micronutrient for humans and animals health,[] and it has been shown to play an important role as an anticancer agent in animal and clinical applications.[] The mechanism for the toxic effects of Se has been proposed to occur attributable to its pro-oxidant ability to accelerate the oxidation of ROS, which can disrupt components of cells through lipid peroxidation.[] Numerous studies[] reported that Se is an important dietary element for animals as well as humans, and there is increasing evidence for the efficacy of certain forms of Se as cancer-chemopreventive compounds

Nishida, H

Int J cancer 2000;85:857-64