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It enables large endogenous neuropeptides, enzymes, growth factors, transferrin and hormones, among the others, to penetrate the BBB harnessing their specific receptors that are highly expressed on the luminal side of endothelial as widely discussed in (Saraiva et al., 2016) and further explained, with representative examples, in section Preclinical achievements of polymeric nanoparticles-mediated drug delivery in Alzheimers disease. The same strategy can also be exploited to deliver drugs against AD into the brain, using surface-modified polymeric NPs as further described in section Polymer functionalization strategies, or even circulating exosomes (Wang et al., 2019)

Perhaps this results from hematologic or lymphatic transplantation of endometrial cells

They protect the retina from blue light, reduce strain, and support visual clarity

Multifunctionality and possible medical application of the BPC 157 peptide: literature and patent review

Molecular characterization of lymphatic endothelial cells

The specific mechanisms remain under investigation, but the finding adds another dimension to DSIP's systemic regulatory effects